Hello! I'm Catherine

I'm a datascientist and data lover. I'm positive and project oriented. I like connecting with people and I'm great at ideation. I'm a hard worker, curious and data oriented. I feel multi-potentialist. Feel free to contact me!

Catherine SIRVEN

DIGITAL TRANSFORMATION AND INNOVATION

Phone:

+33 6 64 94 04 77

Email:

catsi.new@free.fr

EXPERIENCE

EDUCATION

2020

Digital Transformation and collaboration

within Computational Life Science Strategy

BAYER CROPSCIENCE LYON

Animate and push forward the digital fluency topic within Small Molecule research (950 employee worldwide) through the animation of a network of about 60 digital ambassadors.
Referenced best practices of digital trainings and resources to infuse tech culture (Reconciliation of both bottom up and top down approaches).

2017-2019

Senior Computational Life Science

Portfolio Manager

BAYER CROPSCIENCE LYON

Identify novel state-of-the-art computational methods and technologies applicable to research in Crop Science.
Maintain a database of more than 700 innovative startup.
Evaluate and implement pilot projects to create additional value for the R&D pipeline. About 7 innovative project launched and followed.
Collaboration with the internal and external digital world to drive integration of cutting-edge technologies. Good relation obtained and maintained with cutting edge universities.
Special focus on Artificial intelligence for Drug design. Review of external companies and set up of user requirements to put in place collaborative projects.
Special focus on Digital Phenotyping. Innovative usage of Image analysis to minimise screening time and maximise efficiency while generating data asset.
Keep track and implement solutions for data capture, curation and usage.

2013-2016

Team leader « New technologies,

Genetic regulation »

Project leader Trait Disease control

BAYER CROPSCIENCE LYON

Team leader of 10 employees including 3 Lab leaders (organization and facilitation of meetings, presentation of activities, choice of the orientations of the labs).
Follow up of the activity of reporter line design to detect small molecules activity on plant defense modulation.
Follow up of the activity of cloning and validation (zygotie, transgene insertion, expression of RNA and proteins) of arabidopsis and soybean lines generated in the lab by the cellular biology lab.
Set up of screening projects to detect the activities of bacterial extracts, proteins, peptides and small RNA active against soybean rust.
Set up and follow up of external collaborations on the team thematic (ETH Zurich, University of Hohenheim, RWTH Aachen, Oregon State University, University of Georgia).

2009-2013

Lab leader in bioinformatics

Bioinformatics support to lab activities : bioanalysis, phylogeny, statistics, data treatment in particular for the projects Thiazolylpiperidines, Fosetyl, Isotianil, AMSF1772, Pyrimethanil, MENDEL for plant defense modulators.
Group leader by interim in January and February 2013 (facilitation and meeting organisation, presentation of biochemistry in meetings, administrative tasks).
Set up and follow up of external collaborations : Caprotec (Germany) for affinity target search ; ActivX (US) for kinase activity follow up ; Hohenheim University, Pr. Dr. R. T. Voegele for effector search and usage for silencing in soybean rust; UMR5240, Dr V. Girard (France, UMR5240 Bayer/CNRS/university) for the set-up of a proteomic project for Mode of Action discovery.
Proposal and participation in innovative projects between Bayer entities (Life Science Fund): chromatin modulation and epigenetic analysis in plants and mammalian with in particular the study of "small RNAs in the context of biotic stress".
Treatment of high throughput sequencing data (New Generation sequencing). Search of small RNA induced during plant infection (miRNA). RNAseq for the transcriptom of oomycetes species after Thiazolylpiperidines treatment.
Participation in strategic review “Omics factory” for the small molecule part of Bayer Cropscience. Evaluation of global past and future ressources and possible collaborations in phenomics and bioinformatics (NGS, transcriptomic, …)

2006-2009

Head of bioinformatics Monheim

BAYER CROPSCIENCE MONHEIM

Management of the bioinformatics team including 3 technicians (bioanalyst, developers, database administrator), 1 PhD and 2 internship.
Implementation of the bioinformatics strategy in relation to allocated budget. Primary contact person for all bioinformatics related topics including software contracts with coordination of negotiation.
Provide bioinformatics support and know-how to customers in chemistry, biology and biochemistry to ensure the most efficient utilization of highly diverse biological data. In depth analysis including homology search, phylogeny, motif analysis, statistics.
Project manager for evaluation and focused development of valuable algorithms and software tools for custom laboratory work : storage of biological sample monitored for treatment response to compound, molecular biological vectors, transgenic strains or microarray data...
Literature survey in bioinformatics, benchmarking of new technologies and implementation /
adaptation of innovative solutions in relation to the in-house experiments.

2003-2006

Computer scientist in Biology, Bioanalyst

BAYER CROPSCIENCE LYON

Set up of an analysis pipeline (quality control, data handling) for expression profiling with microarrays (two colours or Affymetrix).
Bioanalysis (structural and functional annotation, phylogeny, motif search, transcription factor search, homology/paralogy) on target of fungicides products.
Project management for laboratory specific application development. Data storage of quantitative PCR and microarray results.
Window person for the joint work on the Genome sequencing project Botrytis cinerea (Génoscope/URGI) between Bayer Cropscience and joint research unit CNRS (UMR5240).

2001-2003

Research scientist in Molecular Biology

In charge of the development and use of quantitative PCR methods and tools within the laboratory. Development of qPCR methods based on gene expression profiling for antifungal compound mode of action diagnostic.
Monitoring of commercial fungicides resistance occurrence by allele specific quantitative PCR (SNP detection).

EDUCATION

1998-2001

Master's Degree

POLYTECH CLERMONT

“Ingénieur” grade / MS in Biological Engineering.

University school of engineering in Clermont Ferrand, France.

Specializing in protein engineering and the setting up of companies.

Internship in UMR5240 Aventis Cropscience, CNRS Lyon.

Recombinant protein cloning. Biochemical and kinetic study of Arabidopsis thaliana arogenate dehydratase (target of herbicidal compounds in the amino acid plant pathway).

1995-1998

Preparative Course to the French "Grandes Ecoles"

LYCEE LA MARTINIERE ET FAURIEL

Preparative course to the French “Grandes Écoles” in Physics and Chemistry, Lyon and Saint-Etienne, France

1995

High school diploma in science

LYCEE SAINT MARC

Baccalauréat Scientifique. Graduated magna cum laude, Lyon, France

SKILLS

Data science

Life Science in Biology: biochemistry, plant biotechnology

Open Innovation

Project management

Big data and data asset management

Dry lab for chemistry and drug discovery.

French, English, German

EXPERTISE IN PROJECT MANAGMENT

EXPERTISE

INFRASTRUCTURE PROJECT MANAGEMENT

Matrix management of a team of 14 people including Biology department members but also support functions like site management, budget, controlling, Health and Safety executive.
Set up of an action plan to determine the future organization of labs and offices corresponding to team structures and allocated budget (over 2 million euros over 3 years) and time constraint (work engaged starting in 2012)
Work follow up for the 2 first phases of project implementation.

MULTICULTURAL PROJECT MANAGEMENT

Project leader « ASR trait : Asian Soybean Rust resistance through biotechnology »

Main objective is to obtain a proof of concept (technical and regulatory) regarding Asian Soybean Rust control through genetically modified plants.
Project organization and facilitation for the equivalent of 11 full time employees located in US, Belgium and France for creation of soybean resistant to Rust.
Ideation, prioritization of concepts, ideas and constructs and follow up of screening strategies. Set up of adapted academic collaborations, patent follow up and search of technologies through license agreement.

PUBLIC /PRIVATE PROJECT SET UP

• Set up of an international public project for soybean rust sequencing. External funding obtained through JGI (Joint Genome Institute, US) on a project call with different parties (EMBRAPA Brazil, Hohenheim University, RWTH Aachen, Université de Lorraine).

Aim is to push this huge and full of repetitive element fungal genome in post genomic area through analysis of small RNA, methylation and histone modification during infection.

• Participation in botrytis genomic sequencing by providing bio-analysis skills on specific protein family thema likes kinases, phosphatases, GPCRs, chitinases as well as structural annotation.

PUBLICATIONS

PATENTS AND PUBLICATIONS

PATENTS

Fungal Rust-inducible Promoter. Patent WO2018217474.
Use of Isothiazolecarboxamides to create latent host defenses in a plant. Patent WO2012084858.
Thienylpyri(mi)dinylazole and their use for controlling phytopathogenic fungi. Patent WO2011076725.
Phenylpyri(mi)dinylazoles. Patent WO2011042389.

PUBLICATIONS

Genome-wide analyses of chitin synthases identify horizontal gene transfers towards bacteria and allow a robust and unifying classification into fungi. I.R. Goncalves et al. BMC Evol Biol., vol 16(1), p.252, 2016.
Involvment of a plant defenses enhancer Fosetyl-Al in Flowering induction: From field to the genes. C. Sirven et al. Acta horticulturae, vol. 1094, p83-89, 2015.
Host defense inducers. V. Toquin et al. Modern Crop Protection Compounds V2, W. Kraemers and U. Schirmer editors, Wiley, Weinheim, 2011.
Genomic Analysis of the Necrotrophic Fungal Pathogens Sclerotinia sclerotiorum and Botrytis cinerea. J. Amselem et al. PLoS Genet., vol 7(8), 2011.
Fungi have three tetraspanin families with distinct functions. K. Lambou et al. BMC Genomics, vol. 3, p. 9-63, 2008.
Fluopicolide, a new anti-oomycetes Fungicide with a new Mode of Action inducing perturbation of a Spectrin-like protein. V. Toquin et al. Modern Crop Protection Compounds, p. 675-682, W. Kraemers and U. Schirmer editors, Wiley, Weinheim, 2007.
A new mode of action for fluopicolide : modification of the cellular localization of a spectrin-like protein. V. Toquin et al. Pflanzenschutz Nachrichten, vol. 59 (2), p. 171-184, 2006.
Resistance to fenamidone : Monitoring by real-time quantitative PCR on Plasmopara viticola. C. Sirven, R. Beffa. Pflanzenschutz Nachrichten, vol. 56 (3), p. 523-532, 2003.

CONFERENCES

Organization of Elixir SME forum “ Data driven innovation in the agritech sector” in the LifeHub Lyon 21/22 March 2020 shifted to 10/11 March 2021.
Organization of Perkin Elmer user meeting, in the LifeHub Lyon 2019. 70 users cross company to leverage novelties around data science.
Toward an automatic Bean Rust disease quantification platform using hyperspectral sensing and Deep Learning. Gelibert A. et al. IAMPS, Lyon 2019.
Chemical enhancers of RNA silencing increase antiviral resistance in planta. Jay et al. MPMI, Rhodes, 2014.
Involvement of a plant defenses enhancer fosetyl-Al in flowering induction: from the field to the genes. Sirven C. et al. 12th International Pear Symposium, Leuven, 2014.
Trigger off endogenous plant defences by isotianil, a new resistance inducer. Braun et al. Modern Fungicides and Antifungal Compounds VII, Friedrichroda, 2013.
Comparison of the transcriptomic biomarker signatures in vine and Arabidopsis thaliana attacked by Downy mildews with or without fosetyl-al Stimulators of plant defences pre-treatment. Latorse M-P. et al. Natural products and biocontrol, Perpignan, 2012.
Comparison of fosetyl-Al and another phosphonate on plant downy mildew protection and on Arabidopsis thaliana gene expression. Sirven C. et al. Proceedings of the 6th Workshop of Grapevine Downy and Powdery Mildew, Bordeaux, 2010.
PCR-based method for detecting mutation allele frequencies for QoI resistance in Plasmopara viticola. C. Sirven et al. In Proceedings of the BCPC International Congress Pests and Diseases, p. 823-828, 2002.

INVITED SEMINARS, INNOVATION EVENT AND MEETUPS

Member of Elixir Industry Advisory Committee (IAC) since 2020.
Invited lecture at The Sainsbury laboratory (UK) 2020.
Representing Bayer at Lyon Startup events. Promotion LSU8 to LSU11 (Jury and Prize). In partenariat with the Fondation Pour L'Université de Lyon since 2018.
Jury member for the Women in Operation Research Bayer Scholarship, to promote women in analytics or operation research. 2018-2019.
Representing Bayer at Lyon Startup events. Promotion LSU8 and LSU9. In partenariat with the Fondation Pour L'Université de Lyon.
Meetup with Lyon Data Science: Data for plant science : la donnée au service de l’Ag-tech. With A. Gelibert and A. Thebault, Carbon Bee. Lyon, France Avril 2019.
ELIXIR 5th Anniversary, Open data for impact and Innovation. Panel discussion on innovation based on open life science data. Chair: Hannes Rothe, Assistant Professor, Free University of Berlin. Bruxelles, Belgium, December 2018.
ELIXIR Innovation and SME Forum: Data Driven Innovation in Industrial Biotechnology. Computational life-science in agtech: opportunities and challenges, Frankfurt, Germany, October 2018.
Quelles innovations dans le monde de la protection des plantes, pour répondre au double défi alimentaire et environnemental de demain?, INSA de Lyon, january 2013.
Genedata Expressionist applied in Bioinformatics, Genedata User Group Meeting, Basel, Switzerland, october 2008.
Perspektiven des Scientific Computing bei Bayer CropScience. Institut für Botanik III, Heinrich- Heine Universität Düsseldorf, Germany, september 2008.
Bioinformatics in Crop Protection. Kolloquium Mathematik und Technik, RheinAhrCampus Remagen, Germany, january 2008.
Bioinformatics workshop. MPI für Terrestrische Mikrobiologie, Philipps-Universität Marburg, Germany, february 2007.
Bioinformatique dans l'industrie. Conférence pour découvrir le monde industriel. CUST - Ecole d'ingénieur, Clermont-Ferrand, France, december 2005.

CONTACT

Hello! I'm Catherine

Catherine SIRVEN

DIGITAL TRANSFORMATION AND INNOVATION

​

Phone:

+33 6 64 94 04 77

Email:

catsi.new@free.fr

​

​

EXPERIENCE

EDUCATION

2020

2017-2019

2013-2016

2009-2013

2006-2009

2003-2006

2001-2003

EDUCATION

1998-2001

1995-1998

1995

SKILLS

EXPERTISE IN PROJECT MANAGMENT

INFRASTRUCTURE PROJECT MANAGEMENT

​

MULTICULTURAL PROJECT MANAGEMENT

​

PUBLIC /PRIVATE PROJECT SET UP

​

PATENTS AND PUBLICATIONS

PATENTS

​

PUBLICATIONS

​

CONFERENCES

​

​

INVITED SEMINARS, INNOVATION EVENT AND MEETUPS

​